Pharmaceutical Sciences

Clinical Academic Group (CAG) Leadership

David TaylorCAG Leader
Professor David Taylor

The Pharmaceutical Sciences CAG comprises three of the UK’s leading trust pharmacy departments – Guy’s and St Thomas’ NHS Foundation Trust, King’s College Hospital NHS Foundation Trust and South London and Maudsley NHS Foundation Trust – as well as the newly created Institute of Pharmaceutical Science (IPS) at King’s College London and the Quintiles Guy’s Drug Research Unit.

Of the 1,500 people in the Pharmaceutical Sciences CAG, there are many pharmacists (most of whom are qualified at least to master’s level) and significant numbers of scientists, medical doctors, pharmacy technicians, pharmacy/pharmacology students (undergraduate and postgraduate) and administrative and support staff. Staff in the Pharmaceutical Sciences CAG contribute to teaching at IPS on these courses via informal arrangements, honorary positions and joint appointments.

Guy’s and St Thomas’
The pharmacy department at Guy’s and St Thomas’ provides dispensing services from both hospitals and a full clinical pharmacy service to its wards and departments. In addition to meeting the pharmaceutical care needs of the 750,000 patients who use Guy’s and St Thomas’ hospitals each year, the pharmacy is also home to two ‘regional’ pharmacy specialties, Medicines Information and Pharmacy Quality Assurance. It also incorporates a sterile manufacturing unit, and a non-sterile, licensed manufacturing unit. Dispensing is automated on the St Thomas’ site and e-Prescribing is being evaluated on three wards. A clinical trials supplies unit is closely linked to the manufacturing departments. The specialist pharmacists supporting the South East London Cancer Network are also based within the Guy’s and St Thomas’ pharmacy.

King’s College Hospital
The pharmacy department at King’s College Hospital provides dispensing services and a full clinical pharmacy service based on the clinical specialist model to the 950 inpatient beds and associated outpatient clinics of the hospital. It incorporates a licensed sterile manufacturing unit and a clinical trials supplies unit (maintaining 150 medicines trials). E-prescribing is well established. Medicines Information is provided from Guy’s. King’s College Hospital pharmacy is a UK leader in innovative methods of assuring patient safety in respect to medicines.

South London and Maudsley

The pharmacy department at South London and Maudsley provides dispensing services from three hospitals (Maudsley, Lambeth and Bethlem Royal) and a clinical pharmacy service to 1,000 inpatients and 3,000 community patients. The Medicines Information centre at the Maudsley is the national centre for information on psychotropics. South London and Maudsley pharmacy produces the Maudsley Prescribing Guidelines which is the standard text for prescribing advice in most countries. E-prescribing is under development with a pilot planned.

Quintiles Guy's Drug Research Unit (GDRU)
The Quintiles GRDU carries out commercially sponsored Phase I/II studies of investigational drugs, including first-in-human studies. Quintiles is a global company with offices in over 50 countries and headquarters in North Carolina, USA. Quintiles GDRU has over 20 years’experience in translational medicine and has performed first-in-human studies with over 400 new small molecules and biologics. The unit is recognised internationally for its expertise in preclinical and regulatory strategy combined with innovative Phase I study design. Since its inception, Quintiles GDRU has established a collaboration with senior clinical and academic staff from KCL and GST, to get specialist advice and practical input covering many therapeutic areas. This has involved consultants in allergy, anaesthetics, cardiology, dermatology, immunology, respiratory medicine, gastroenterology, haematology, microbiology, nephrology, neurology, psychiatry, rheumatology and urology.

Institute of Pharmceutical Science, King's College London
The Institute of Pharmaceutical Science (IPS) provides undergraduate education and a range of postgraduate courses including Pharmaceutical Sciences and PhD programmes in a variety of fields. Staff in IPS are focused on gaining a detailed understanding of the human pathological state and safely employing this knowledge to discover, design, develop and deliver drugs to the patient with a view to treating or managing disease. Research focuses on the following themes: clinical practice and medication use; drug delivery (e.g. dermal, transdermal, pulmonary, gastrointestinal); synthetic chemistry (drug discovery); chemical biology; pharmaceutical biophysics; and pharmacology and therapeutics (lung biology, pulmonary pharmacology, blood brain barrier).

Click here to download a poster about the Pharmaceutical Sciences CAG. Please note this is an A0 poster.

Clinical Academic Group (CAG) Lead
Professor David Taylor, Director of Pharmacy and Pathology, Pharmacy Department, South London and Maudsley NHS Foundation Trust and Professor of Psychopharmacology at King's College London.

Selected recent publications
A comparison of the clinical effectiveness and costs of mental health nurse supplementary prescribing and independent medical prescribing: a post-test control group study
Norman IJ, Coster S, McCrone P, Sibley A and Whittlesea C (2010) BMC Health Services Research 10: 4

Allergen induces the migration of platelets to lung tissue in allergic asthma
Pitchford SC, Momi S, Baglioni S, Casali L, Giannini S, Rossi R, Page CP and Gresele P (2008) American Journal of Respiratory and Critical Care Medicine 177: 604-612

Amido-3-hydroxypyridin-4-ones as Iron (III) Ligands
Piyamongkol S, Ma YM, Kong XL, Liu Z D, Aytemir MD, van der Helm D and Hider RC (2010) Chemistry - A European Journal 16(21): 6374-6381

Analysis of the bacterial communities present in the lungs of Cystic Fibrosis patients from American and British centers
Stressmann FA, Rogers GB, Klem ER, Lilley AK, Donaldson SH, Daniels TW, Carroll MP, Patel N, Forbes B, Boucher RC, Wolfgang MC and Bruce KD (2011) Journal of Clinical Microbiology 49: 281-291

Challenges in inhaled product development and opportunities for open innovation
Forbes B, Asgharian B, Dailey LA, Ferguson D, Gerde P, Gumbleton M, Hardy C, Hassall D, Gustavsson L, Jones R, Lock R, Maas J, McGoverin T, Pitcairn G, Somers G and Wolff R (2011) Advanced Drug Delivery Reviews 63: 69-87

Dendrimeric Nanocontainers as Anti-angiogenic Therapeutics
Al-Jamal K T, Akerman S, Podesta J E, Al-Jamal WT, Turton JA, Kanthou C, Vargesson N, Tozer GM and Kostarelos K (2010) Proceedings of the National Academy of Science 107: 3966-3971

Development and validation of the Medication-Related Consultation Framework (MRCF)
Abdel-Tawab R, James DH, Fichtinger A, Clatworthy J, Horne R and Davies G (2011) Patient Education and Counseling 83(3): 451-7

Efficacy of drug treatments for generalised anxiety disorder: systematic review and meta-analysis
Baldwin D, Woods R, Lawson R and Taylor D (2011) British Medical Journal 342: d1199

Evaluating three theory-based interventions to increase physicians’ recommendations of smoking cessation services
Vogt F, Hall S, Hankins M and Marteau TM (2009) Health Psychology 28(2): 172-182

Lipid chain geometry of C14 glycerol-based lipids: effect on lipoplex structure and transfection
Kudsiova L, Ho J, Fridrich B, Harvey R, Keppler M, Ng T, Hart SL, Tabor AB, Hailes HC and Lawrence MJ (2011) Molecular Biosystems 7(2): 422-36

Phytochemical informatics and Traditional Chinese Medicine and therapeutic relevance
Ehrman TM, Barlow DJ and Hylands PJ (2007) Journal of Chemical Information and Modeling 47(6): 2316-2334

Robotic multiwell planar patch-clamp for native and primary mammalian cells
Milligan CJ, Li J, Sukumar P, Majeed Y, Dallas ML, English A, Emery P, Porter KE, Smith AM, McFadzean I, Beccano-Kelly D, Bahnasi Y, Cheong A, Naylor J, Zeng F, Liu X, Gamper N, Jiang LH, Pearson HA, Peers C, Robertson B and Beech D (2009) Nature Protocols 4: 244-255

Structural contributions to the intracellular targeting strategies of antimicrobial peptides
Lan Y, Ye Y, Kozlowska J, Lam JKW, Drake AF, Mason AJ (2010) Biochimica et Biophysica Acta - Biomembranes 1798(10): 1934-1943

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition
Pesnot T, Jørgensen R, Palcic MM and Wagner GK (2010) Nature Chemical Biology 6: 321-323

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