Prenatal stress could affect baby's brain, say researchers

New research from King’s College London has found that maternal stress before and during pregnancy could affect a baby’s brain development.

In the study, published in Biological Prenatal_baby_brain_image_stress.jpgPsychiatry, Medical Research Council Doctoral Researcher in Perinatal Imaging and Health, Alexandra Lautarescu and Head of Advanced Neuroimaging, Professor Serena Counsell, looked at the relationship between maternal stress and brain development in 251 premature babies for the first time.  

They found evidence for the impaired development of a white matter tract, the uncinate fasciculus, in babies whose mothers experienced more stress in the prenatal period.

The mothers completed a questionnaire which asked them about their experiences of stressful events, which ranged from everyday stress such as moving house or taking an exam, to more severe stressors like experiencing bereavement, separation or divorce. A score of severity of stress was calculated based on how many stressors they experienced as well as how severe those stressors were. This is what was related to the baby’s brain.

The researchers used a medical imaging technique called diffusion tensor imaging that was specifically developed to look at the structure of the white matter. The white matter tract has previously been implicated in anxiety disorders – adults that have an anxiety disorder may show changes in this tract. 

We found that in the mums that were more stressed during pregnancy and the period before birth, white matter was altered in the babies,

said lead researcher Alexandra Lautarescu from King’s College London. 

Scientists say the study highlights the importance of providing support for expectant mothers. Clinicians have an important role to play when speaking with expectant mothers. While questions are asked about depressive symptoms, few questions are asked about general stress and anxiety. Women who deal with stressful life events during pregnancy are not always picked up by their GPs or by their health care providers. 

It is not diagnosed as often as it should be during pregnancy and we are trying to emphasise that maternal mental health during pregnancy can impact the baby’s brain development which may impact on their outcomes later in life.
If we try to help these women either during the pregnancy or in the early post-natal period with some sort of intervention this will not only help the mother, but may also prevent impaired brain development in the baby and improve their outcomes overall. 

 Alexandra Lautarescu said.

There is some evidence to suggest that if mothers experience poor mental health during pregnancy that leads to adverse outcomes in the baby – obstetric outcomes, lower birth weight or premature birth. Further studies are needed to understand whether the observed changes in the brain development of these babies will lead to adverse outcomes later in life.

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