Why are some of us hungry all the time?

New research by ZOE and King’s College London shows that people who experience big dips in blood sugar levels end up feeling hungrier and consuming hundreds more calories during the day than others.

fruit and vegThe PREDICT (Personalised Responses to Dietary Composition Trial) study, supported by a research team from King’s College London and health science company ZOE, has determined why some people struggle to lose weight, even when on calorie-controlled diet.

The PREDICT study is the largest ongoing nutritional research programme in the world that looks at responses to food in real life settings, and its results highlight the importance of understanding personal metabolism when it comes to diet and health.

The research team collected data about blood sugar responses and other markers of health from 1,070 people after eating standardised breakfasts and freely chosen meals over a two-week period, adding up to more than 8,000 breakfasts and 70,000 meals in total.

The standard breakfasts were based on muffins containing the same number of calories but varying in composition in terms of carbohydrates, protein, fat and fibre. Participants also carried out a fasting blood sugar response test to measure how well their body processes sugar. Participants wore stick-on continuous glucose monitors (CGMs) to measure their blood sugar levels over the duration of the study, as well as a wearable device to monitor activity and sleep. They also recorded levels of hunger and alertness using a phone app, along with exactly when and what they ate over the day.

Previous studies looking at blood sugar after eating have focused on the way that levels rise and fall in the first two hours after a meal, known as a blood sugar peak. However, data from PREDICT found that some people experienced significant ‘sugar dips’ two to four hours after this initial peak, where their blood sugar levels fell rapidly below baseline before coming back up.

Those who experienced significant dips in blood sugar had a nine percent increase in hunger, and waited around half an hour less, on average, before their next meal than those who only experienced a small dip, even though they ate the same meals. They also ate 75 more calories in the three to four hours after breakfast and around 312 calories more over the whole day than little dippers. This pattern could potentially turn into 20 pounds of weight gain over a year.

Dr Sarah Berry from the School of Life Course Sciences at King’s College London, said:

It has long been suspected that blood sugar levels play an important role in controlling hunger, but the results from previous studies have been inconclusive. We’ve now shown that sugar dips are a better predictor of hunger and subsequent calorie intake than the initial blood sugar peak response after eating, changing how we think about the relationship between blood sugar levels and the food we eat.

Prof Ana Valdes from the School of Medicine at the University of Nottingham, who led the study team, said:

Many people struggle to lose weight and keep it off, and just a few hundred extra calories every day can add up to several pounds of weight gain over a year. Our discovery that the size of sugar dips after eating has such a big impact on hunger and appetite has great potential for helping people understand and control their weight and long-term health.

Comparing what happens when participants eat the same test meals revealed large variations in blood sugar responses between people. The researchers also found no correlation between age, bodyweight or BMI and being a big or little dipper, although males had slightly larger dips than females on average.

There was also some variability in the size of the dips experienced by each person in response to eating the same meals on different days, suggesting that this depends on individual differences in metabolism, as well as the day-to-day effects of meal choices and activity levels.

Choosing foods that work together with your unique biology could help people feel fuller for longer and eat less overall.

Lead author on the study, Patrick Wyatt from ZOE, notes,

This study shows how wearable technology can provide valuable insights to help people understand their unique biology and take control of their nutrition and health. By demonstrating the importance of sugar dips, our study paves the way for data-driven, personalized guidance for those seeking to manage their hunger and calorie intake in a way that works with rather than against their body.

Prof Tim Spector, Professor of Genetic Epidemiology at the School of Life Course Sciences, concludes,

Food is complex and humans are complicated, but our research is finally starting to open up the black box between diet and health. We’re excited to have been able to turn this cutting-edge science into an at-home nutrition and microbiome test so that everyone has the opportunity to discover their unique responses to food to best support their metabolism and gut health.

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